diff --git a/radicale/storage.py b/radicale/storage.py
index f84cb68..f649807 100644
--- a/radicale/storage.py
+++ b/radicale/storage.py
@@ -1217,6 +1217,38 @@ class Collection(BaseCollection):
             pass
         return content
 
+    _cache_locks = {}
+    _cache_locks_lock = threading.Lock()
+
+    @contextmanager
+    def _acquire_cache_lock(self, ns=""):
+        with contextlib.ExitStack() as lock_stack:
+            with contextlib.ExitStack() as locks_lock_stack:
+                locks_lock_stack.enter_context(self._cache_locks_lock)
+                lock_id = ns + "/" + self.path
+                lock = self._cache_locks.get(lock_id)
+                if not lock:
+                    cache_folder = os.path.join(self._filesystem_path,
+                                                ".Radicale.cache")
+                    self._makedirs_synced(cache_folder)
+                    lock_path = None
+                    if self.configuration.getboolean(
+                            "storage", "filesystem_locking"):
+                        lock_path = os.path.join(
+                            cache_folder,
+                            ".Radicale.lock" + (".%s" % ns if ns else ""))
+                    lock = FileBackedRwLock(lock_path)
+                    self._cache_locks[lock_id] = lock
+                lock_stack.enter_context(lock.acquire_lock(
+                    "w", lambda: locks_lock_stack.pop_all().close()))
+            try:
+                yield
+            finally:
+                with self._cache_locks_lock:
+                    lock_stack.pop_all().close()
+                    if not lock.in_use():
+                        del self._cache_locks[lock_id]
+
     def _load_item_cache(self, href):
         cache_folder = os.path.join(self._filesystem_path, ".Radicale.cache",
                                     "item")
@@ -1267,25 +1299,38 @@ class Collection(BaseCollection):
             href)
         vobject_item = None
         if input_hash != cache_hash:
-            try:
-                vobject_items = tuple(vobject.readComponents(
-                    raw_text.decode(self._encoding)))
-                if len(vobject_items) != 1:
-                    raise RuntimeError(
-                        "Content contains %d components" % len(vobject_items))
-                vobject_item = vobject_items[0]
-                check_and_sanitize_item(vobject_item, uid=uid,
-                                        tag=self.get_meta("tag"))
+            # Lock the item cache to prevent multpile processes from generating
+            # the same data in parallel. This is only needed for performance.
+            if self._lock.locked() == "w":
+                # The access is already exclusive, use dummy context manager.
+                lock = contextlib.suppress()
+            else:
+                lock = self._acquire_cache_lock("item")
+            with lock:
+                # Check if another process created the file in the meantime.
                 cache_hash, uid, etag, text, tag, start, end = \
-                    self._store_item_cache(href, vobject_item, input_hash)
-            except Exception as e:
-                raise RuntimeError("Failed to load item %r in %r: %s" %
-                                   (href, self.path, e)) from e
-            # Clean cache entriesn once after the data in the file system was
-            # edited externally.
-            if not self._item_cache_cleaned:
-                self._item_cache_cleaned = True
-                self._clean_item_cache()
+                    self._load_item_cache(href)
+                if input_hash != cache_hash:
+                    try:
+                        vobject_items = tuple(vobject.readComponents(
+                            raw_text.decode(self._encoding)))
+                        if len(vobject_items) != 1:
+                            raise RuntimeError("Content contains %d components"
+                                               % len(vobject_items))
+                        vobject_item = vobject_items[0]
+                        check_and_sanitize_item(vobject_item, uid=uid,
+                                                tag=self.get_meta("tag"))
+                        cache_hash, uid, etag, text, tag, start, end = \
+                            self._store_item_cache(
+                                href, vobject_item, input_hash)
+                    except Exception as e:
+                        raise RuntimeError("Failed to load item %r in %r: %s" %
+                                           (href, self.path, e)) from e
+                    # Clean cache entries once after the data in the file
+                    # system was edited externally.
+                    if not self._item_cache_cleaned:
+                        self._item_cache_cleaned = True
+                        self._clean_item_cache()
         last_modified = time.strftime(
             "%a, %d %b %Y %H:%M:%S GMT",
             time.gmtime(os.path.getmtime(path)))
@@ -1471,8 +1516,12 @@ class FileBackedRwLock:
             return "r"
         return ""
 
+    def in_use(self):
+        with self._lock:
+            return self._waiters or self._readers or self._writer
+
     @contextmanager
-    def acquire_lock(self, mode):
+    def acquire_lock(self, mode, sync_callback=None):
         def condition():
             if mode == "r":
                 return not self._writer
@@ -1482,6 +1531,8 @@ class FileBackedRwLock:
         # Use a primitive lock which only works within one process as a
         # precondition for inter-process file-based locking
         with self._lock:
+            if sync_callback:
+                sync_callback()
             if self._waiters or not condition():
                 # Use FIFO for access requests
                 waiter = threading.Condition(lock=self._lock)