diff --git a/radicale/__init__.py b/radicale/__init__.py
index b6da193..a9b4c41 100644
--- a/radicale/__init__.py
+++ b/radicale/__init__.py
@@ -358,6 +358,9 @@ class Application:
         environ["PATH_INFO"] = storage.sanitize_path(environ["PATH_INFO"])
         self.logger.debug("Sanitized path: %s", environ["PATH_INFO"])
         path = environ["PATH_INFO"]
+        if base_prefix and path.startswith(base_prefix):
+            path = path[len(base_prefix):]
+            self.logger.debug("Stripped script name from path: %s", path)
 
         # Get function corresponding to method
         function = getattr(self, "do_%s" % environ["REQUEST_METHOD"].upper())